Preheat the oven to 400°F (200°C).
Pound chicken breasts to an even thickness (about 1/2 inch) and season both sides with salt and pepper.
Place flour in a shallow dish. In another shallow dish, whisk eggs with water. In a third dish, combine Italian breadcrumbs, panko, 1/2 cup Parmesan cheese, garlic powder, oregano, and red pepper flakes.
Dredge each chicken breast in flour, shaking off excess, then dip into the egg mixture, and coat thoroughly in the breadcrumb mixture.
Heat vegetable oil in a large skillet over medium-high heat. Fry chicken breasts for 3–4 minutes per side until golden and crispy. Transfer to a paper towel-lined plate.
Place fried chicken on a baking sheet. Spoon marinara sauce evenly over each piece, sprinkle with mozzarella and remaining Parmesan.
Bake for 10–12 minutes, until cheese is melted and bubbly.
Garnish with fresh basil and serve over cooked spaghetti or pasta of choice.