Preheat oven to 375°F (190°C) and grease a muffin tin with non-stick cooking spray.
Flatten each biscuit dough piece and press into the muffin tin, forming small cups.
Spoon a tablespoon of pizza sauce into each cup.
Top with shredded mozzarella cheese and pepperoni slices.
Sprinkle with garlic powder, Italian seasoning, and red pepper flakes if desired.
Bake for 12-15 minutes or until golden brown and cheese is bubbly.
Allow to cool for a few minutes before serving.