In a medium bowl, combine the chopped ham, mayonnaise, Dijon mustard, sweet relish, garlic powder, onion powder, smoked paprika, and hot sauce.
Mix until all ingredients are well incorporated and the texture is creamy.
Taste and adjust seasoning with salt, pepper, or additional hot sauce as needed.
Chill the salad for at least 30 minutes before serving for best flavor.
Serve with crackers, on sandwich bread, or in lettuce cups. Garnish with green onions if desired.