In a skillet over medium heat, cook ground beef until no longer pink. Drain excess grease.
Stir in the pasta sauce, salt, garlic powder, Italian seasoning, and onion powder. Set aside.
In a bowl, mix cottage cheese, sour cream, and egg until combined.
Spray the inside of the slow cooker with non-stick spray.
Layer as follows: sauce, uncooked pasta, cheese mixture, and shredded mozzarella. Repeat layers, ending with sauce and mozzarella.
Sprinkle Parmesan cheese on top.
Cover and cook on LOW for 4–5 hours or until pasta is tender.
Garnish with chopped basil or parsley before serving, if desired.