Preheat oven to 375°F (190°C).
In a mixing bowl, combine the cream cheese, sour cream, and mayonnaise until smooth.
Stir in Italian seasoning, garlic powder, and onion powder.
Fold in mozzarella cheese, parmesan, and diced pepperoni.
Transfer the mixture to a baking dish and smooth the top.
Bake for 20-25 minutes until bubbly and golden on top.
Serve hot with crackers, bread, or veggies for dipping.