Season the ground beef with salt, black pepper, chili powder, and garlic powder. Mix well and shape into two large patties.
Heat a skillet over medium-high heat and cook the patties for about 3-4 minutes per side until fully cooked.
In a separate pan, melt butter and lightly toast the tortillas on both sides.
Place a cooked patty on a tortilla, sprinkle cheese on top, and cover with another tortilla.
Cook the quesadilla burger for 1-2 minutes per side until golden brown and the cheese melts.
Remove from heat, carefully lift the top tortilla, and add lettuce, tomatoes, onions, jalapeños, and chipotle mayo.
Serve immediately with fries or a side salad.